Bioclavid/Bioclavid Forte Side Effects

Side effects occurring on co-amoxiclav therapy are generally mild and they rarely result in discontinuation of therapy. The following side effects are possible: Gastrointestinal: Diarrhea, nausea, vomiting and digestive disturbances may occur occasionally but they are of transient nature. They can be attenuated by intake of the preparation at mealtime. Colonization of the intestine by candida and isolated cases of pseudomembranous colitis have been described after amoxicillin therapy. Studies of effects on the intestinal flora have reported promotion of colonization by resistant enterobacteria and a reduction in staphylococci.
Hypersensitivity Reactions: Skin rash, pruritus, urticaria, fever and joint pain can occur occasionally. Further reactions eg, angioneurotic edema, anaphylaxis, erythema multiforme exudativum, Stevens-Johnson syndrome, exfoliative dermatitis have been observed in rare cases. Treatment with co-amoxiclav should be discontinued if skin rashes occur. Patients with viral infections tend to respond more frequently with cutaneous reactions. Rare cases of interstitial nephritis have been reported.
Hematological Changes: Leukopenia, thrombocytopenia, agranulocytosis and eosinophilia have been reported. Likewise, prolongation of the bleeding and prothrombin time has been observed. The development of positive Coombs' test has been reported. Isolated cases of behavioral changes (aggression, irritability) have been observed in pediatric patients and elevated urea nitrogen or creatinine levels have been reported.
Liver: Changes of hepatic function parameters (SGOT and SGPT) have been observed in isolated cases. Transient hepatitis and cholestatic jaundice have been reported in rare cases.